HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

W Joseph Thompson Selected Research

sulindac sulfone (exisulind)

7/2008Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G.
2/2005Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells.
6/2004Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells.
10/2003Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells.
9/2003Phase I and II study of exisulind in combination with capecitabine in patients with metastatic breast cancer.
5/2003Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival.
3/2003Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cells.
11/2002Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation.
11/2002beta-Catenin signaling: therapeutic strategies in oncology.
8/2002Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G.
For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown:


W Joseph Thompson Research Topics

Disease

8Neoplasms (Cancer)
07/2008 - 03/2002
6Colonic Neoplasms (Colon Cancer)
07/2008 - 01/2002
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2003 - 03/2002
2Carcinoma (Carcinomatosis)
03/2003 - 04/2002
1Retinoblastoma (Glioblastoma, Retinal)
10/2004
1Prostatic Neoplasms (Prostate Cancer)
10/2003
1Breast Neoplasms (Breast Cancer)
09/2003
1Heart Failure
05/2003
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/2003
1Barrett Esophagus (Barrett's Esophagus)
03/2003
1Adenocarcinoma
03/2003
1Glioblastoma (Glioblastoma Multiforme)
04/2002
1Glioma (Gliomas)
04/2002
1Gliosarcoma
04/2002
1Neoplasm Metastasis (Metastasis)
03/2002
1Lung Neoplasms (Lung Cancer)
03/2002
1Ischemia
02/2002

Drug/Important Bio-Agent (IBA)

12sulindac sulfone (exisulind)IBA
07/2008 - 03/2002
8Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
07/2008 - 03/2002
5Cyclic GMPIBA
10/2004 - 03/2002
4Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
07/2008 - 04/2002
2EnzymesIBA
07/2008 - 03/2002
2Cyclin D1IBA
06/2004 - 11/2002
2Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
10/2003 - 03/2002
2Docetaxel (Taxotere)FDA Link
05/2003 - 03/2002
2beta CateninIBA
11/2002 - 11/2002
1Meclofenamic Acid (Meclofenamate)FDA LinkGeneric
07/2008
1GuanosineIBA
07/2008
1Celecoxib (Celebrex)FDA Link
07/2008
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
07/2008
1Indomethacin (Indometacin)FDA LinkGeneric
07/2008
1Phosphodiesterase 5 InhibitorsIBA
02/2005
13',5'-Cyclic-AMP Phosphodiesterases (3',5' Cyclic Nucleotide Phosphodiesterase)IBA
10/2004
1AndrogensIBA
10/2003
1sulindac sulfideIBA
10/2003
1Androgen Receptors (Androgen Receptor)IBA
10/2003
1Capecitabine (Xeloda)FDA Link
09/2003
1Messenger RNA (mRNA)IBA
05/2003
1DEAE-TrisacrylIBA
05/2003
1Cyclic NucleotidesIBA
05/2003
1Protein Isoforms (Isoforms)IBA
05/2003
1Glycogen Synthase Kinase 3 betaIBA
11/2002
1diethylstilbestrol monophosphate (PDES)IBA
11/2002
1SulfonesIBA
03/2002
1Sulindac (Copal)FDA LinkGeneric
03/2002
1taxaneIBA
03/2002
1RolipramIBA
02/2002
1Proteins (Proteins, Gene)FDA Link
01/2002
1RNA (Ribonucleic Acid)IBA
01/2002
1Glutathione Transferase (Glutathione S-Transferase)IBA
01/2002

Therapy/Procedure

2Therapeutics
03/2003 - 11/2002
1Aftercare (After-Treatment)
05/2003
1Chemoprevention
03/2003